The first episode begins with House and Cuddy escaping Princeton- Plainsboro Teaching Hospital together on a beach. Katie Jacobs has talked about a possible working relationship, but acknowledges that both characters do not have spotless pasts.
Meanwhile, Remy Hadley takes personal leave and her position is taken over by a bright young medical student (Amber Tamblyn) whose only fault is that she’s not quite qualified as a physician.
| No. | Episode | Air Date | ||
| 1 | Now What? | 9/20/2010 | ||
| 2 | Selfish | 9/27/2010 | ||
| 3 | Unwritten | 10/4/2010 | ||
| 4 | Massage Therapy | 10/11/2010 | ||
| 5 | Unplanned Parenthood | 10/18/2010 | ||
| 6 | Office Politics | 11/8/2010 | ||
| 7 | A Pox on Our House | 11/15/2010 | ||
| 8 | Small Sacrifices | 11/22/2010 | ||
| 9 | Larger Than Life | 1/17/2011 | ||
| 10 | Carrot or Stick | 1/24/2011 | ||
| 11 | Family Practice | 2/7/2011 | ||
| 12 | You Must Remember This | 2/14/2011 | ||
| 13 | Two Stories | 2/21/2011 | ||
| 14 | Recession Proof | 2/28/2011 | ||
| 15 | Bombshells | 3/7/2011 | ||
| 16 | Out of the Chute | 3/14/2011 | ||
| 17 | Fall From Grace | 3/21/2011 | ||
| 18 | The Dig | 4/11/2011 | ||
| 19 | Last Temptation | 4/18/2011 | ||
| 20 | Changes | 5/2/2011 | ||
| 21 | The Fix | 5/9/2011 | ||
| 22 | After Hours | 5/16/2011 | ||
| 23 | Moving On | 5/23/2011 |
